Thursday, November 8, 2007

Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis

Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis

By Robert A. Copeland
Publisher: Wiley-VCH
Number Of Pages: 397
Publication Date: 2000-03-15
Sales Rank: 449250
ISBN / ASIN: 0471359297
EAN: 9780471359296
Binding: Hardcover
Total Reviews: 5

Book Description:

Fully updated and expanded-a solid foundation for understanding experimental enzymology.

This practical, up-to-date survey is designed for a broad spectrum of biological and chemical scientists who are beginning to delve into modern enzymology. Enzymes, Second Edition explains the structural complexities of proteins and enzymes and the mechanisms by which enzymes perform their catalytic functions. The book provides illustrative examples from the contemporary literature to guide the reader through concepts and data analysis procedures. Clear, well-written descriptions simplify the complex mathematical treatment of enzyme kinetic data, and numerous citations at the end of each chapter enable the reader to access the primary literature and more in-depth treatments of specific topics.

This Second Edition of Enzymes: A Practical Introduction to Structure, Mechanism, and Data Analysis features refined and expanded coverage of many concepts, while retaining the introductory nature of the book. Important new features include:

A new chapter on protein-ligand binding equilibria
Expanded coverage of chemical mechanisms in enzyme catalysis and experimental measurements of enzyme activity
Updated and refined discussions of enzyme inhibitors and multiple substrate reactions
Coverage of current practical applications to the study of enzymology
Supplemented with appendices providing contact information for suppliers of reagents and equipment for enzyme studies, as well as a survey of useful Internet sites and computer software for enzymatic data analysis, Enzymes, Second Edition is the ultimate practical guide for scientists and students in biochemical, pharmaceutical, biotechnical, medicinal, and agricultural/food-related research.

Pharmacotherapy of Diabetes: New Developments: Improving Life and Prognosis for Diabetic Patients

By Carl Erik Mogensen
Publisher: Springer
Number Of Pages: 318
Publication Date: 2007-09-05
ISBN-10 / ASIN: 0387697365
ISBN-13 / EAN: 9780387697369
Binding: Hardcover

Book Description:

In the United States, 20.8 million children and adults, 7% of the population, have diabetes. While an estimated 14.6 million have been diagnosed, 6.2 million have yet to be diagnosed. Worldwide diabetes afflicts 150 million people. The World Health Organization estimates that by 2025 that figure will double. Diabetes is responsible for more deaths than AIDS and breast cancer, combined. It is a leading cause of blindness, kidney failure, amputations, heart complications and stroke.

Treatment of Type 1 and Type diabetes has changed radically over the past few years. There are new opportunities for treating the key abnormality in diabetes, increased blood glucose, by effective agents such as new insulin preparations and oral agents.

Increasing so-called non-glycemic intervention is of prime importance. Blood pressure lowering therapies, anti-cholesterol strategies, and specific treatment related to complications is becoming increasingly important.

Pharmacotherapy of Diabetes is a unique, invaluable guide to all aspects of the pharmacological treatment of diabetes, covering basic concepts and an in-depth review of current and future therapies. This work provides an overview for the new changes in therapies that can be implemented in clinical practice and treatment of the diabetic patient.
Size: 3.9 MB rar, pdf

Type: 278p PDF
Size: WinRAR-compressed to 3.97 MB
MD5: 69b3fce6103c9693152ecaa30661b8e1

Glucokinase And Glycemic Disease: From Basics to Novel Therapeutics

Glucokinase And Glycemic Disease: From Basics to Novel Therapeutics (Frontiers in Diabetes)

Author: F. M. Matschinsky (Editor), M. A. Magnuson (Editor)
Product Details
406 pages, S. Karger Publishers (USA) (June 3, 2004) $234.75
Format: 2.5MB PDF
ISBN / ASIN: 3805577443
The glucose-phosphorylating enzyme glucokinase (also known as hexokinase IV) plays a preeminent role as a glucose sensor and regulatory metabolic enzyme. The implications of this central position of glucokinase for the understanding and treatment of diabetes mellitus are far reaching. This book addresses the molecular and human genetic, as well as the physiological-chemical and pharmacological aspects of the role glucokinase plays in glucose homeostasis and diseases of glucose metabolism, and how the enzyme serves as the drug target for the treatment of diabetes mellitus. The collection of assays by a team of internationally renowned authors includes basic science chapters dealing with the enzymology, structure and the kinetics of hexokinases, essays describing the biochemical genetics of glucokinase-linked hypo- and hyperglycemia syndromes, and papers that discuss the diverse roles of the enzyme in a variety of tissues. 72981431

Format: PDF
Archive: RAR
Size: 2.19 MB
MD5: 8563889a5c35649c1836d54260566358

Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome

Type 2 Diabetes, Pre-Diabetes, and the Metabolic Syndrome

By Ronald A. Codario
Publisher: Humana Press
Number Of Pages: 272
Publication Date: 2005-05-15
ISBN-10 / ASIN: 1588294714
ISBN-13 / EAN: 9781588294715
Binding: Hardcover
Book Description:

Well-known and highly respected diabetes authority Ronald A. Codario, MD, details for busy primary care practitioners the state of the art in diagnosing and managing diabetes, as well as in reducing patient risk factors. Using an evidence-based approach, Dr. Codario explains, in simple clinical terms that avoid the complexity of much larger textbooks, our latest understanding of the pathophysiology of diabetes, its treatment with insulin and oral agents, and the management of its risk factors. The author also extensively reviews such major topics as the metabolic syndrome, the role of exercise and nutrition, and the key issues associated with the use of herbs and nutraceuticals. Also included are continuing medical education (CME) questions that provide the opportunity to acquire up to a maximum of 10 AMA/PRA category 1 CME credits. For the past 15 years, the author has given CME lectures on diabetes throughout the country.

1 MB rar, pdf

Type: 257p PDF
Size: WinRAR-compressed to 0.91 MB

Neural Development and Stem Cells

Neural Development and Stem Cells (Contemporary Neuroscience)

By Mahendra S. Rao

Publisher: Humana Press
Number Of Pages: 468
Publication Date: 2005-09-15
ISBN-10 / ASIN: 1588294811
ISBN-13 / EAN: 9781588294814
Binding: Hardcover

Book Description:

This extensively expanded and updated edition reflects the enormous increase in our knowledge of the development of the nervous system. Working from a new understanding that the regionalization of stem cells occurs early in development and that this bias appears to persist even after prolonged culture, Dr. Rao has added additional chapters on olfactory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. A new chapter on cell death summarizes the important changes in the death pathway that occurs as stem cells mature. Special attention is paid to the derivation of neural cells from embryonic stem cells. Authoritative and up-to-date, Neural Development and Stem Cells, Second Edition provides neuroscientists with a handy guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes.

4.3 MB rar, pdf
Type: 451p PDF
Size: WinRAR-compressed to 4.33 MB
MD5: 4c38f094e5ddb5774ddf99e9060c00dc

Stress and Hypertension: Examining the Relation between Psychological Stress and High Blood Pressure

Stress and Hypertension: Examining the Relation between Psychological Stress and High Blood Pressure (Current Perspectives in Psychology)

By Kevin T. Larkin
Publisher: Yale University Press
Number Of Pages: 416
Publication Date: 2005-11-11
ISBN-10 / ASIN: 0300106440
ISBN-13 / EAN: 9780300106442
Binding: Hardcover
Book Description:

Does living a stress-filled life lead to elevated blood pressure? And if so, do strategies to better manage stress effectively lower blood pressure? In this authoritative and comprehensive book, Kevin T. Larkin examines more than a half-century of empirical evidence obtained to test the common assumption that stress is associated with the onset and maintenance of essential hypertension (high blood pressure).

While the research confirms that stress does play a role in the exacerbation of essential hypertension, numerous other factors must also be considered, among them obesity, exercise, and smoking, as well as demographic, constitutional, and psychological concerns. The author discusses the effectiveness of strategies developed to manage stress and thereby lower blood pressure and concludes with suggestions and directions for further study.

Angiogenesis and Direct Myocardial Revascularization

  • Angiogenesis and Direct Myocardial Revascularization (Contemporary Cardiology)
  • Publisher: Humana Press
  • Number Of Pages: 372
  • Publication Date: 2005-05-15
  • Sales Rank: 2305923
  • ISBN / ASIN: 1588291537
  • EAN: 9781588291530
  • Binding: Hardcover
  • Manufacturer: Humana Press
  • Studio: Humana Press
  • Average Rating: 0
  • Total Reviews: 0

Book Description:

An interdisciplinary panel of pioneers and opinion leaders review the basic, preclinical, clinical, and developmental pathways to new treatment strategies, such as therapeutic angiogenesis and myogenesis. The authors take advantage of new biological understanding, novel therapeutic targets, multiple available and well-studied therapeutic strategies, and the necessary imaging techniques to measure outcomes. Their in-depth discussions cover the identification of new therapeutic targets and pathways, the investigation of transcriptional factors, master switch molecules, cell-based approaches, chemokines, a better understanding of the effects of aging, endothelial dysfunction, and hypercholesterolemia in response to angiogenic stimuli. Highlights include examination of drug delivery problems, outcomes measure, stem therapy, high-risk interventions, development pathways, and future possibilities.